Just Published:
Distinct cortical-amygdala projections drive reward value encoding and retrieval
Malvaez M, Shieh C, Murphy, MD, Greenfield VY, Wassum KM.
Nature Neuroscience (2019) Free Full PDF

Just Published:
Nucleus accumbens cholinergic interneurons oppose cue-motivated behavior
Collins AL, Aitken TJ, Huang I, Shieh C, Greenfield VY, Monbouquette HG, Ostlund SB, Wassum KM.
Biological Psychiatry (2019)

2/25/19
Congratulations to Nina Lichtenberg for receiving the BRI Eva Kavan award and the APA Dissertaiton award!!!

7/2018
Congratulations to Ana Sias on receiving the Translational neuroscience of drug abuse training grant and joining the lab!

Just Published:
Habits are negatively regulated by histone deacetylase 3 in the dorsal striatum
Malvaez M, Greenfield VY, Matheos DP, Angelillis NA, Murphy MD, Kennedy PJ, Wood MA , Wassum KM
Biological Psychiatry (2019) In Press

Regulation of habit formation in the dorsal striatum
Malvaez M, Wassum KM.
Current Opinion in Behavioral Science (2018) 20:67-74.

SfN posters:
November 15, 2017, 8:00 AM
697.18. Cortical-amygdala circuits for value-based decision making
*M. MALVAEZ1, C. SHIEH1, M. MURPHY1, V. Y. GREENFIELD1, H. G. MONBOUQUETTE2, K. M. WASSUM1;
1Psychology, 2Chem. & Biomolecular Engin., UCLA, Los Angeles, CA
Session: Poster: 697 – Motivation: Subcortical Neurocircuitry

November 15, 2017, 8:00 AM
697.19. The role of basolateral amygdala output pathways in reward expectation-guided behavior
*N. T. LICHTENBERG1, Z. T. PENNINGTON1, V. Y. GREENFIELD1, K. M. WASSUM1,2;
1Psychology, UCLA, Los Angeles, CA; 2Brain Res. Institute, UCLA, Los Angeles, CA
Session: Poster: 697 – Motivation: Subcortical Neurocircuitry

November 15, 2017, 1:00 PM
788.13. Impact of chemogenetic inhibition of mesocorticolimbic dopamine signaling on cue-motivated behavior
*S. B. OSTLUND1, *S. B. OSTLUND1, B. HALBOUT2, K. M. WASSUM3, A. AZIZ2;
1Dept. of Anesthesiol. and Perioperative Care, UCI Sch. of Med., Irvine, CA; 2Anesthesiol., Univ. of California, Irvine, Irvine, CA; 3Psychology, UCLA, Los Angeles, CA
Session: Poster: 788 – Reward: Dopamine, Pharmacology, and Pathophysiology

 

Just Published:
Basolateral amygdala to orbitofrontal cortex projections enable cue-triggered reward expectations
Lichtenberg NT, Pennington ZT, Holley SM, Greenfield VY, Cepeda C, Levine MS, Wassum KM
Journal of Neuroscience (2017)

5/28/17-
Congratulations to Annie Collins on being awarded the Dissertation Year Fellowship Award & Nina Lichtenberg for receiving the Translational neuroscience of drug abuse training grant!

5/25/17-
Congratulations to Tara Aitken on being award the Dean’s Prize for Research Excellence!

3/3/17-
We’re very excited to welcome Dr. Ashleigh Morse to the lab!

2/1/17-
Congratulations to Annie Collins on being awarded UCLA’s Kavan prize!

2/1/17-
Congratulations to Annie Collins on being awarded the Mautner Fellowship & Nina Lichtenberg for receiving the Translational neuroscience of drug abuse training grant!

12/7/16-
Just Published:
Amygdala mu-opioid receptors mediate the motivating influence of cue-triggered reward expectations
Lichtenberg NT and Wassum KM
European Journal of Neuroscience (2016).

8/18/16-
Wassum Lab SfN Posters:
Saturday 11/12 1-5PM
80.06 / CCC26 – Identification of an amygdala-cortical circuit for cue-directed action.
*N. T. LICHTENBERG, V. Y. GREENFIELD, Z. T. PENNINGTON, K. M. WASSUM

80.07 / DDD1 – Glutamate released into the basolateral amygdala tracks reward value encoding and the use of this information to guide reward seeking
*M. MALVAEZ, H. G. MONBOUQUETTE, K. M. WASSUM

Tuesday 11/15 8AM-12PM
542.17 / III6 – Contribution of nucleus accumbens core cholinergic interneuron tonic activity to cue-motivated behavior
*T. AITKEN, A. L. COLLINS, S. B. OSTLUND, K. M. WASSUM

542.16 / III5 – Contribution of nucleus accumbens core cholinergic interneurons to cue-motivated behavior
*A. L. COLLINS, T. J. AITKEN S. B. OSTLUND, K. WASSUM

8/18/16-
Just Published:
Nucleus accumbens acetylcholine receptors modulate dopamine and motivation
Collins AL, Aitken TJ, Greenfield VY, Ostlund SB and Wassum KM
Neuropsychopharmacology (2016).

6/28/16
Congratulations to Melissa Malvaez on being awarded the Scheibel Postdoctoral Lecture Award!

3/29/16
Congratulations to Kenny Amaya on being awarded the NSF GRFP!

2/12/16-
Just Published:
Dynamic mesolimbic dopamine signaling during action sequence learning and expectation violation
Collins AL, Greenfield VY, Bye JK, Linker KE, Wang AS and Wassum KM
Scientific Reports (2016) 6, 20231.

2/10/16-
We currently hiring for a NIH-funded post-doc position. Click here for more information.

1/25/16-
Just Published:
Nucleus accumbens core dopamine signaling tracks the need-based motivational value of food-paired cues.
Aitken TJ*, Greenfield VY* and Wassum KM
Journal of Neurochemistry (2016).

11/16/15-

Just Published:
The Origins and Organization of Vertebrate Pavlovian Conditioning
Fanselow MS and Wassum KM
Cold Spring Harbor perspectives in biology (2015)

11/10/15-
Congratulations to Tara Aiken on becoming a HHURP scholar!

9/23/15-
SfN Posters:

S. J. HERSMAN, J. CUSHMAN, K. WASSUM, M. S. FANSELOW, S. LOTFIPOUR
Sun, Oct 18, 8:00 AM – 12:00 PM
126.05/C2 – Optogenetic activation of medial septum cholinergic neurons improves contextual fear learning and alters choline levels in hippocampus

A. L. COLLINS, V. GREENFIELD, I. XU, S. OSTLUND, K. WASSUM
180. Reward: Dopamine Sun, Oct 18, 8:00 AM – 12:00 PM
180.01/BB19 – Nucleus accumbens core muscarinic and nicotinic acetylcholine receptors differentially modulate phasic dopamine release and mediate cue-induced incentive motivation

S. B. OSTLUND, A. T. LIU, B. HALBOUT, K. M. WASSUM, N. T. MAIDMENT
255. Appetitive and Incentive Learning and Memory I Sun, Oct 18, 1:00 – 5:00 PM
255.21/X3 – Modulation of cue-triggered reward seeking by cholinergic signaling in the dorsomedial striatum

N. T. LICHTENBERG, V. Y. GREENFIELD, A. S. WANG, K. M. WASSUM
258. Reward: Motivational Mechanisms I Sun, Oct 18, 1:00 – 5:00 PM
258.05/Y16 – Basolateral amygdala mu opioid receptor activation and connections to the orbitofrontal cortex mediate outcome-specific Pavlovian-instrumental transfer

A. G. HOWE, K. M. WASSUM, H. T. BLAIR
267. Electrode Arrays I Sun, Oct 18, 1:00 – 5:00 PM
267.16/BB59 – Simultaneous in-vivo single-unit recording and fast-scan cyclic voltammetry in the behaving rat

M. MALVAEZ, S. STOLL, A. M. YORITA, L. FENG, H. G. MONBOUQUETTE, K. M. WASSUM
636. Motivation and Emotion: Reward II Tue, Oct 20, 1:00 – 5:00 PM
636.19/DD25 – Glutamate released into the basolateral amygdala tracks the encoding of reward value and the use of this information to guide reward seeking

9/10/15-
Just published:
The basolateral amygdala in reward learning and addiction
Wassum KM, Izquierdo A.
Neuroscience & Biobehavioral Reviews (2015).

9/8/15-
We’re excited to welcome new grad student Kenny Amaya to the lab!

7/27/15-
Just published:
Basolateral amygdala rapid glutamate release encodes an outcome-specific representation vital for reward-predictive cues to selectively invigorate reward-seeking actions
Malvaez M, Greenfield VY, Wang AS, Yorita AM, Feng L, Linker KE, Monbouquette HG, Wassum KM.
Scientific Reports (2015).

12/23/14-
Just published:
Probing the Neurochemical Correlates of Motivation and Decision Making
Wassum KM, Phillips PEM.
ACS Chemical Neuroscience (2015) 6(1) 11-13.

8/1/2014– Just Published:
Inflated Reward Value in Early Opiate Withdrawal.
Wassum KM, Greenfield, VY, Linker KE, Maidment NT, Ostlund SB.
Addiction Biology (2014) DOI: 10.1111/adb.12172